The role of FcγRs in regulating innate and adaptive immune responses in infection and autoimmunity has been extensively studied.121 For instance, the interactions between the complement system and FcγR signaling have long been studied for their role in rheumatoid arthritis pathogenesis.94,157 Our understanding of FcγRs has mostly derived from myeloid cells, although the functional outcomes they engage will naturally differ depending on the identity of the cell expressing them.60 This evidence concerns the gene FCGR2A and rheumatoid arthritis.