Furthermore, pharmacological inhibition of CCL2 and CCR2 with neutralizing antibody or antagonist, respectively, also attenuates mechanical allodynia induced by peripheral nerve injury.53,227 Neutralization of the CCL2/CCR2 axis also protected from chemotherapy-induced neuropathic pain.3,83 These studies strongly support the role of the CCL2/CCR2 axis in the development of some types of neuropathic pain. Here, CCL2 is linked to peripheral nerve injury.