Nox-derived ROS has been implicated in the pathophysiology of neuropathic pain.94,107 Notably, sNAMs of the sensory ganglia express Nox2 and increase the production of ROS after peripheral nerve injury.96 Altogether these studies indicate that peripheral macrophage–derived ROS, including Nox2 dependent, might be an interesting target for neuropathic pain control. Here, CYBB is linked to peripheral nerve injury.