IL1R1 and arthritic joint disease: Furthermore, the deletion of Il1r1 exclusively in the population of TRPV1+ nociceptors prevented the development of pathological pain in models of arthritis and multiple sclerosis.138 The future use of these Il1r1 conditional mice and the generation of TNF receptors conditional knockout mice in primary nociceptive neurons would be necessary to explore and confirm this possibility in models of neuropathic pain after peripheral nerve injury.