IL27 and neuropathic pain: For instance, we recently found that at the level of sensory ganglia there is an increase in the production of IL-27 which plays a regulatory role in the development of neuropathic pain.52 We also showed that Il-27 counteracts neuropathic pain by acting on its receptor expressed by sNAMs that in turn stimulate the production of the antinociceptive cytokine IL-10.52