It is well established that NOD2 and TLRs act in macrophages' activation, leading to positive pressure in the proinflammatory pathways.72 We recently demonstrated that after peripheral nerve injury, the NOD2 expression is upregulated in sNAMs of the sensory ganglia.175 Using genetic inhibition of NOD2, we showed that NOD2 signaling is involved in sensory ganglia sNAMs activation/accumulation and mediates neuropathic pain development. Here, NOD2 is linked to peripheral nerve injury.