The well-characterized chemokine that brings blood monocytes into inflamed tissues is CCL2.116,204 This chemokine recruits monocytes/macrophages by activating its highly affinity CCR2 receptor.67,185 This axis seems to play an essential role in the neuroinflammation process, including those associated with neuropathic pain development.1,237 In fact, mice lacking CCL2 or CCR2 are resistant to the development of neuropathic pain caused by peripheral nerve injury. This evidence concerns the gene CCL2 and peripheral nerve injury.