TLR4 and peripheral nerve injury: Another pattern recognition receptor (PRR) which has been described as important for neuropathic pain development is TLR4.132 Earlier studies have shown that TLR4 deficient mice are protected from peripheral nerve injury–induced neuropathic pain.17,206 This effect was attributed to reducing microglia activation in the spinal cord.26,197 However, no one has evaluated the impact of TLR4 deficiency in sNAMs activation in the sensory ganglia in models of traumatic peripheral nerve injury.