CD4 and non-Hodgkin lymphoma: Some risk factors have also been identified, such as CD4/CD8 ratio and anti-CMV IgG levels; however, the small number of patients who experienced CMV reactivation in each cohort, the great heterogeneity in type of disease, stage, and previous treatments, and lack of data on younger adults and/or subjects diagnosed with aggressive NHL treated with bendamustine as first-line therapy could not allow the identification of univocal predictors of CMV reactivation.