Among that, compared to control, there was an upregulation of CCL3 and CCR5 expression in SW620 and HT29 lines, NF-κB in all of the three CRC cell lines, while TRAF6 was overexpressed only in HT29 cells, indicating CCL3/CCR5 and NF-κB-related pathways may be closely related to CRC progression. The gene discussed is NFKB1; the disease is colorectal carcinoma.