TRPV4 and neoplasm: A recent study with endothelial-specific TRPV4 knockout mice demonstrates that the specific deletion of endothelial TRPV4 promotes tumor angiogenesis, growth, and metastasis compared to control mice (Kanugula et al., 2021), indicating that endothelial TRPV4 is a critical modulator of vascular integrity and tumor angiogenesis.