Transient receptor potential vanilloid 4 (TRPV4) channels have been reported to play vital roles in the regulation of cardiovascular homeostasis and are critically implicated in the regulation of cardiac remodeling, blood pressure, hypoxic preconditioning, pulmonary hypertension, and pulmonary edema (Randhawa and Jaggi, 2015b). The gene discussed is TRPV4; the disease is pulmonary arterial hypertension.