TRPV4 and heart failure: The TRPV4 antagonist GSK2193874 mitigates the increases in lung weight after heart failure (Michel, 2006; Thorneloe et al., 2012) and TRPV4 inhibition or genetic deletion suppresses pulmonary inflammation and improved pulmonary function in the HCl-and Cl2- induced injury model (Balakrishna et al., 2014).