Recent evidence suggests that activating pulmonary capillary endothelial TRPV4 channels enhance pulmonary venous pressure-induced edema and TRPV4 blockade prevents the increased vascular permeability and pulmonary edema (Thorneloe et al., 2012), highlighting a pharmacological therapeutic potential of TRPV4 inhibition for pulmonary edema induced by heart failure. Here, TRPV4 is linked to heart failure.