Besides directly IL-6 targeting agents, Janus kinase inhibitors reduce IL-6 signaling, and they may have impressive SAA-reducing effects in RA but none of the available drugs (tofacitinib, baricitinib, upadacitinib, and filgotinib) have consistently been evaluated in renal amyloidosis (35). This evidence concerns the gene IL6 and Renal amyloidosis.