Among the variants whose frequency positively correlates with COVID-19 cases, we identified (i) two variants at FCGR2A gene which may potentially decrease the expression of FCGR2C and HSPA7, (ii) one variant in IRF1 gene which may upregulate SLC22A, (iii) a variant in ADORA2B which increases the mRNA expression of CENPV gene in lung, and (iv) 9 variants in GYPB (see below). The gene discussed is IRF1; the disease is COVID-19.