As shown in Figure 1, serum MMP-2 was higher in the S-LAM group [median value: 298 ng/ml, range 277–416 ng/ml], and in the TSC-LAM patients (median value: 293 ng/ml, range 248–480 ng/ml) compared to healthy volunteers (median value: 225 ng/ml, range 203–336 ng/ml) and TSC patients (median value: 232 ng/ml, range 213–323 ng/ml, p = 0.040 of ANOVA). This evidence concerns the gene MMP2 and lymphangioleiomyomatosis.