The cut off value of 800 pg/mL for VEGF-D had sensitivity and specificity for the diagnosis of LAM of 58 and 100%, respectively The ROC AUC for the diagnosis of LAM of VEGF-D was 0.879 ± 0.049 (95% CI: 0.782–0.975, p < 0.001, Figure 2A). The gene discussed is VEGFD; the disease is lymphangioleiomyomatosis.