Serum MMP-7 was higher in TSC-LAM patients (median value: 4.78 ng/ml, range 3.5–5.3 ng/ml) with even greater values in patients with TSC-LAM minimal pulmonary disease (median value: 5.69 ng/ml, range: 4.90–7.43 ng/ml) than in S-LAM patients (median: 3.39 ng/ml, range: 3.16–4.35) and in controls (median: 2.99 ng/ml, range 2.62–3.59 ng/ml, p = 0.001 of ANOVA). Here, MMP7 is linked to tuberous sclerosis.