Activation of TFEB and TFE3 is observed in other cancer types such as lung, pancreatic ductal adenocarcinoma (PDA), breast, prostate, and colorectal, but it is not associated with chromosomal translocations or FLCN mutations (Liang et al., 2018; Torres et al., 2018; Perera et al., 2019). Here, TFE3 is linked to pancreatic ductal adenocarcinoma.