Activation of TFEB and TFE3 is observed in other cancer types such as lung, pancreatic ductal adenocarcinoma (PDA), breast, prostate, and colorectal, but it is not associated with chromosomal translocations or FLCN mutations (Liang et al., 2018; Torres et al., 2018; Perera et al., 2019). The gene discussed is TFE3; the disease is cancer.