C5AR1 and Sepsis: For example, Qi Anlong reported that anti C5a monoclonal antibody may improve the prognosis of sepsis by improving the polarization of spleen mature DC and T cells, which indicates that C5a plays an important role in the immune regulation of sepsis cells (16); Many animal experiments have found that complement components can promote histone production, further leading to cell damage and multiple organ dysfunction in septic mice.