In the multivariate analysis, with results reported as odds ratio (95% CI), young age (0.97 [0.94-1.00]), high BMI (1.14 [0.99-1.31]), high Ki67 (1.02 [1.00-1.04]), large tumor size (4.29 [2.88-6.39]), indistinct tumor margins (0.29 [0.10-0.79]), calcified tumor (14.79 [6.45-33.94]), and an aspect ratio ≥1 (0.05 [0.02-0.13]) were independent predictive factors associated with the risk of SLN metastasis (Table 3). The gene discussed is MKI67; the disease is neoplasm.