At the same time, functional studies also showed that a high concentration of 2-HG was detected in the SPCRP with IDH2 mutation, and global DNA hypermethylation and H3K27 trimethylation were observed in the SPCRP with IDH1/IDH2 mutations (72), which was consistent with the cancer characteristics of IDH1/IDH2 mutation. This evidence concerns the gene IDH2 and cancer.