High frequent mutations in IDH2 have been found in AML, glioma, chondrosarcoma, angioimmunoblastic T cell lymphoma (AITL) and solid papillary carcinoma with reverse polarity (SPCRP), and IDH2 mutations were also reported in other malignant tumors (Table 2, Figure 3). This evidence concerns the gene IDH2 and central nervous system cancer.