The same corresponding mutations occurring in SMARCA1, SMARCA4, and SMARCA2 (components of a closely related chromatin remodeling complex known as SWI//SNF) cause Schimke immune-osseous dysplasia, Coffin–Siris syndrome and Nicolaides–Baraitser syndrome (32, 47, 53, 54). Here, SMARCA1 is linked to Coffin-Siris syndrome.