Moreover, the large number of somatic mutations in CHD4 seen in different cancer types (carcinomas, gliomas, medulloblastoma, hematopoietic, and lymphoid) in different tissues (gynecological, nervous system, lymphoid organs, intestine, kidney, lung, etc.) (31–38) make this epigenetic regulator worthy of attention. Here, CHD4 is linked to central nervous system cancer.