Conclusions were that CHD4 coactivates HIF to promote breast tumor growth, and that different mRNAs were also up-regulated in human breast tumors (ZMYND8, KDM4C (JMJD2C), CDK8, CREBBP (CBP), KAT), suggesting the heterogeneity of epigenetic regulation of HIF in breast cancer. This evidence concerns the gene ZMYND8 and breast neoplasm.