RHAMM, that is, receptor for hyaluronan-mediated motility, has been shown to have extracellular functions (i.e., it coordinates HA-induced cell growth and motility with other cell surface receptors in lung cancer) and intracellular functions (i.e., it modulates cytoskeletal organization through interaction with microtubules and actin filaments and contributes to ERK activation in breast cancer) [123]. The gene discussed is HMMR; the disease is lung cancer.