In vivo imaging of the epithelium of BM blood vessels revealed that the vasculature expresses the adhesion molecule E-selectin and the chemoattractant stromal-cell-derived factor 1 in discrete, discontinuous areas that influence the homing ability of a variety of tumor cell lines inside the BM, and that these specific molecules determine a microenvironment for early BM tumor metastasis [34]. Here, CXCL12 is linked to neoplasm.