A GWAS comparing non‐affected and affected GB dogs would be desirable to identify if nasal hyperkeratosis in GB is an inherited disease as in other breeds with familiar hyperkeratosis, and what gene(s) may be responsible or if the hyperkeratosis may be directly or indirectly associated with brachycephalic genes such as SMOC2 and BMP3 gene.10, 11. This evidence concerns the gene SMOC2 and Hyperkeratosis.