Salidroside could activate the TGF-β1/Smad3 signaling pathway in ischemic stroke model mice, inhibit Bax expression, and promote the expression of Bcl-2, TGF-β1, and p-Smad3, thereby reducing the damage of nerve function and playing a protective role on nerve cells [22]. The gene discussed is SMAD3; the disease is ischemic stroke.