NUDT1 and neoplasm: Li et al. have investigated the action of hyperbranched polymer- releasing drugs in acidic intracellular environments, TH287 (the MTH1 protein inhibiter) and anticancer drug sodium arsenite (an anticancer drug) can be loaded into hyperbranched poly(amine-ester) (HPAE) through electrostatic attraction and hydrophobic interaction, and TH287 renders more sensitive to drugs after inhibiting MTH1 in the tumor cell [126].