MAPT and Parkinson disease: Epigenomic changes associated with other genes, including hypomethylation of NPAS2 (Lin et al., 2012) and CYP2E1 (Kaut et al., 2012) and hypermethylation of PGC1-α (Su et al., 2015) and the H1 haplotype of Tau (MAPT) (Coupland et al., 2014), have also been implicated in PD.