TLR4 and type 1 diabetes mellitus: In 2015, a total of 28 SNPs associated with TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR8, and TLR9 were genotyped in China, many of which were not studied in previous genome-wide association studies (GWAS), and showed for the first time that SNPs of TLR1 (rs5743612, -626; rs4833095, -1017) may play a crucial role in the etiology of T1DM (55).