UBE2D3 and psoriasis: More importantly, tnfaip3 and tnip1 genes play key roles to regulate NF-κB signaling in psoriasis, and Ebosin can increase the expression of A20, a key player in the negative feedback regulation of NF-kappaB signaling encoded by tnfaip3, which has been reported to attenuate NF-κB signaling pathway by editing the ubiquitination of proximal signaling proteins including TRAF6, MALT1, RIPK1, NEMO, UBCH5C, etc (44).