Also, the presence of ACE2 receptors for the viral S protein in endothelial cells correlates with the frequent vascular complications of COVID-19 resulting from endotheliitis and microvascular brain injury (4) that induces the host’s immune response with cytokine storm, hyperinflammation, coagulopathy, thrombosis and embolism resulting in ischemic and hemorrhagic strokes and multisystemic complications affecting lungs, heart, kidneys and liver. Here, ACE2 is linked to COVID-19.