A subsequent study by Spranger et al. used adoptive T cell transfer to address this and found that still, adoptively transferred effector T cells failed to traffic to the tumor site and this was due to the absence of CXCL9/10 production from CD103+ dendritic cells (those with the ability to cross-present extracellular antigen to CD8+ T cells) (19). This evidence concerns the gene CD8A and neoplasm.