FOXP3, RORγt, STAT3, RelA/p65 (NF-κB), and c-Fos/c-Jun (AP-1) are transcription factors targeted by SIRT1, which are well-studied and are crucial to a balanced immune system, but the role of SIRT1 in autoimmune disease is only in the incipient stage, especially in the progression of SLE. Here, FOXP3 is linked to autoimmune disease.