FOXP3, RORγt, STAT3, RelA/p65 (NF-κB), and c-Fos/c-Jun (AP-1) are transcription factors targeted by SIRT1, which are well-studied and are crucial to a balanced immune system, but the role of SIRT1 in autoimmune disease is only in the incipient stage, especially in the progression of SLE. This evidence concerns the gene NFKB1 and autoimmune disease.