Drug exposure led to an increased nuclear localization of ER-β subtype, with no modifications of the ER-α subcellular localization, leading to the hypothesis that the cytotoxic and antiproliferative effects of tamoxifen in ACC cells could be mediated by its ER-β agonist activity, according to previous observations (38). The gene discussed is ESR1; the disease is adrenal cortex carcinoma.