SF-1, also known as Ad4-binding protein or NR5A1, binds as a monomer to nuclear receptor half sites on DNA (44), and it plays an important role not only in adrenal steroidogenesis but also in cell adhesion, cell proliferation, apoptosis, and angiogenesis of adrenocortical tumor cells (36). This evidence concerns the gene NR5A1 and adrenal cortex neoplasm.