MAPK8 and early-onset autosomal dominant Alzheimer disease: The protein encoded by Jun, jun proto-oncogene, a transcription factor involved in JNK-mediated transcriptional changes, has been identified as a crucial part in the mediation of TLR4-dependent neuroinflammation and in the ocular degeneration occurring in an Alzheimer’s disease mouse model (Badshah et al., 2016; Buccarello et al., 2017).