MMP2 and hepatocellular carcinoma: In hepatocellular carcinoma (Guo et al., 2020b) and cervical cancer (Sun et al., 2020a), it has been demonstrated that Icariside II could weaken the migratory and invasive ability of HuH-7, HepG2, and HeLa cells through inhibiting metastasis-related protein MMP2/9 expression.