Nude mice xenografts, established using HCC cells, were treated with 25 mg/kgd Icariside II for 30 days and exhibited a remarkable reduction in tumor volume, weight, and the protein levels of MMP2/9 and BCL-2/Bax ratio compared to the DMSO-treated group (Guo et al., 2020a). This evidence concerns the gene MMP2 and hepatocellular carcinoma.