NLRP3 and diabetes mellitus: Of note, the nucleotide-binding and oligomerization (NACHT) domain, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3 (NLRP3) inflammasome-mediated inflammatory cascade has been suggested to contribute to the deficiencies in angiogenesis and ulcer healing in DM patients (Mirza et al., 2013; Zhang et al., 2017; Liu et al., 2019; Huang et al., 2020).