Many oncogenic proteins involve in the cancer progression including signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor, which participates in the cell apoptosis (Kim and Park, 2018; Wu et al., 2019), proliferation and autophagy (You et al., 2015; Furtek et al., 2016; Kim et al., 2017; Fathi et al., 2018; Li et al., 2018). The gene discussed is STAT3; the disease is cancer.