PPAR-α can improve dysfunction of glucose metabolism in T2DM by increasing insulin sensitivity, reducing hyperglycaemia and hyperinsulinaemia (Hong et al., 2018; Zhang et al., 2018; Xu et al., 2006), and alleviate insulin resistance to decrease the incidence of diabetes (Feng et al., 2019). The gene discussed is INS; the disease is type 2 diabetes mellitus.