APOE and dementia: A series of previous studies have shown that miR-195 is involved in dementia-related pathological processes by targeting multiple genes (Ai et al., 2013; Sun et al., 2015; Liu et al., 2016; Chen et al., 2017; Cao et al., 2020; Mao et al., 2020) and up-regulation of miR-195 in the hippocampus and cortex could improve the cognitive function of CBH rats (Ai et al., 2013) and ApoE4+/+mice (Cao et al., 2020).