Furthermore, FPR-1 antagonist cyclosporin H reduced neutrophil recruitment in acid-induced lung inflammation (Dorward et al., 2017), and formyl peptides have been reported to be present in tobacco leaves and FPRs promoted the progression of COPD in smokers (De Cunto et al., 2020a) ,which further elicited FPR-1 inhibition might provide a novel insight into inflammation control in COPD. This evidence concerns the gene FPR1 and chronic obstructive pulmonary disease.