Mass spectrometric analysis identified annexin A1 and its receptor formyl peptide receptor 1 (FPR1) as a key mediator of keratinocyte death and blocking annexin A1 with antibody attenuated the disease, suggesting that necroptosis pathway mediated by annexin 1 contributed to SJS/TEN (Saito et al., 2014). Here, FPR1 is linked to toxic epidermal necrolysis.