Afterward, a number of studies showed HLA-B*58:01 is a high-risk factor of allopurinol-induced skin reactions in Mainland Han Chinese (Cao et al., 2012; Chiu et al., 2012; Cheng et al., 2015a), Thai (Tassaneeyakul et al., 2009; Sukasem et al., 2016), Korean (Kang et al., 2011), European (Lonjou et al., 2008), and Japanese (Dainichi et al., 2007; Kaniwa et al., 2008), with 229.7, 203.40, 127.60 (Han Chinese), 348.3 (Thai), 97.8 (Korean), 80 (European), and 40.83 (Japanese) fold risk than noncarriers. Here, HLA-B is linked to skin reaction.