Further, we evaluated the Spearman’s coefficient correlations (r) between CD4+Treg cells before (B) after (A) of LGS, and CD4+ subpopulations at the baseline of naïve, effector memory (TEM), and central memory (TCM) at baseline with metabolic parameters, adipokines, and chemokines, pro-inflammatory cytokines in class III obesity group, as shown in Supplementary Tables and Figures (Tables S3, S4 and Figure S8). This evidence concerns the gene CD4 and obesity disorder.