To gain more about the effect of LGS on biomarkers related to obesity and inflammation, we evaluated the effect of LGS on the concentrations of the following biomarkers in the plasma; acute phase protein (hsCRP), adipokines (leptin and adiponectin), pro-inflammatory cytokines (TNF-α, IL-6, and IL-10) and chemokine (MCP-1). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.