FOXM1 and neoplasm: Results showed that combinatorial treatment with Aurora-A kinase inhibitor AKI6038 and FOXM1 inhibitor thiostrepton in MDA-MB-231 cells yielded strong growth inhibition and suppression of colony, mammosphere and xenograft tumour formation, with respect to the single drugs administered alone, confirming that inhibition of Aurora-A and FOXM1 synergistically impairs the growth of BCSC [33].