Accordingly, their expression patterns oscillate upon their respective depletion or overexpression; interestingly, depletion of FOXM1 in MDA-MB-231 (high Myc) breast cancer cells was able to reduce not only Aurora-A levels, consistent with the FOXM1 transcription regulation of AURKA gene, but also Myc levels [33, 48]. The gene discussed is FOXM1; the disease is breast cancer.