UBE2C and neoplasm: We note that UBE2C, an E2 enzyme whose coding gene is located, as is the AURKA genomic locus, in the 20q chromosome arm frequently amplified in tumours, may represent an interesting candidate; indeed increased Aurora-A and UBE2C levels in cancer positively correlate, with the two genes occurring within cancer-related signatures, and an interaction between them has been reported [63–65].