Therefore, in the present studies, we used sevoflurane and desflurane as clinically relevant tools and employed nanobeam-sensor as the approach to test a hypothesis that tau and/or p-tau can exit from neurons and enter microglia, which increases the generation of interleukin 6 (IL-6), a pro-inflammatory cytokine, leading to cognitive impairment. Here, IL6 is linked to Cognitive impairment.