Additionally, expression of Bcl6, a transcription factor required for germinal center entry13, was significantly higher (p < 0.01) among the expanded ILCFR population in HIV+ compared to HIV− individuals (Fig. 6d, e), suggesting that ILCFR are not only expanded in HIV infection, but are also more likely to be located within the germinal center follicle compared to in the absence of infection. The gene discussed is BCL6; the disease is HIV infectious disease.