HMGB1 and interstitial lung disease: When the bleeding volume was co-analyzed with HMGB1, a combination of “higher HMGB1 and higher bleeding volume” was associated with the highest incidence of AE-ILD (46.2%), compared to those with either HMGB1-high or bleeding volume-high (11.7%) and those with neither (3.2%) (Fig. 3b).