In the present study, we sought to evaluate histone H3 acetylation status in surgically resected samples of pancreatic cancer ex vivo, investigate the effect of in vitro HAT inhibition on cell proliferation and cell cycle distribution using the HAT inhibitor C646, and evaluate the inhibitory efficacy of C646 on tumor growth in vivo. The gene discussed is TMPRSS11D; the disease is pancreatic neoplasm.