Stoklosa et al. (2008) found that increased level of reactive oxygen species (ROS) resulted in accumulation of DNA lesions in BCR-ABL positive CML (Chronic Myeloid Leukaemia) cells which was associated with inhibition of MMR functions leading to increased genomic instability5. Here, MRC1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.