In addition, in vitro studies using c-9, t-11-CLA have shown several biological effects on neurons, including promotion of proliferation of neuronal progenitor cells15 and protection from glutamate-induced or Aβ-induced neuronal cell death16,17, suggesting beneficial effects of c-9, t-11-CLA on neurodegenerative disorders including AD. Here, SELPLG is linked to Alzheimer disease.