The ten most significantly differentially expressed genes in OSCC-GB tumor tissue included seven upregulated—MMP1, MFAP2, MMP13, PARP12, C1QTNF6, COL4A1, DFNA5—and three downregulated genes—ARHGEF26, NFIA, and CTTNBP2. Earlier studies had found similar features in HNSCC and/or OSCC. Here, COL4A1 is linked to head and neck squamous cell carcinoma.