The NTHL1-het cancers exhibited a broad range of FGA scores (Fig. 1c) that were significantly lower than the PALB2 associated cancers (median 0.20 vs. 0.41, P < 0.001 by Mann-Whitney test) or the RAD51C associated cancers (median 0.20 versus 0.45, P < 0.001) and not statistically significantly different to the FGA scores observed in the sporadic breast cancers (median 0.20 vs. 0.26, P = 0.11). This evidence concerns the gene PALB2 and breast cancer.