While one of the three NTHL1-het cancers showed a minor proportion of SBS30 (C37112, p.(Gln287Ter), Fig. 1b), this was also observed in one of the nine sporadic cancers, suggesting no major difference in mutational processes between NTHL1-het and sporadic control cancers (BC3, Supplementary Fig. 3). The gene discussed is NTHL1; the disease is cancer.