To better understand the pathways underlying feeding-regulated LPS susceptibility in the presence and absence of BMAL1 and a functional molecular clock in hepatocytes, we performed RNAseq, which revealed tight clustering of gene expression in the 12-h starved (NF-ZT12, DF-ZT0) and fed (NF-ZT0, DF-ZT12) groups in Bmal1fl/fl and Bmal1ΔHep, with the groups protected in the LPS sepsis model (Bmal1fl/fl NF-ZT0, DF-ZT12) separated from susceptible groups by the strongest principal component (Supplementary Fig. 6a). The gene discussed is CLOCK; the disease is Sepsis.