Intriguingly, UVR damage or Batimastat treatment of the CSD fibroblast model (CSD-UV) only slightly modulated melanoma invasion (Fig. 3d), possibly indicating the effect of UVR damage to fibroblasts and MMP1 expression is capped, and higher doses of MMP inhibition are required in highly expressing MMP1, CSD-UV fibroblasts. Here, MMP1 is linked to melanoma.