It was found that, in tumor, cytoplasmic lncRNA P53RRA is downregulated and interacts with Ras-GTPase activating protein binding protein 1 (G3BP1) to transfer p53 from the G3BP1 complex, resulting in p53 retention in the nucleus, leading to cell cycle arrest, ferroptosis, and apoptosis45. The gene discussed is TP53; the disease is neoplasm.