Several studies have focused on the role of Fas/FasL signaling during autophagy, and Fas/FasL has been verified to mediate autophagy activation in cell line systems including human neuroblastoma (SH-SY5Y) cells, human lung cancer SPC-A-1 cells and HeLa cells, and Fas signaling could activate autophagic cascades in retina-retinal pigment epithelium (RPE) separation during retinal detachment via regulating the conversion of LC3-I to LC3-II and the expression of Atg5. The gene discussed is FAS; the disease is lung cancer.