RELA and Hepatic fibrosis: Moreover, the phosphorylation of NF-κBp65 (p-p65) was repressed in CCl4-treated p65f/f mice, and p-p65-positive signaling in p65Δhepa mice was only localized in the non-parenchymal cells due to hepatocytes specific NF-κBp65 deletion in p65Δhepa mice (Supplementary Fig. 2a), these data suggest that downregulated or absent NF-κBp65 activity could lead to increase hepatocytes apoptosis in the initiation of liver fibrosis.