Recent study has suggested that miR-196b-5p-mediated downregulation of Fas involved in the activation of STAT3 signaling through the NF-κBp65/IL-6 axis, and Fas downregulation could activate NF-κBp65 signaling to promote lung cancer cell growth in non-small cell lung cancer (NSCLC)48, which powerfully demonstrated the interaction between Fas/FasL and NF-κBp65. The gene discussed is STAT3; the disease is lung cancer.