By using mouse model, we found that CCl4 injection-induced prominent liver fibrosis in mice as shown by α-SMA and COL-I staining, which was accompanied with obvious apoptosis and Fas/FasL upregulation (Fig. 1a, b), and western blotting further represented that the levels of Fas, FasL, α-SMA, COL-I, COL-IV, and cleaved caspase-3 were enhanced in the fibrotic sections (Fig. 1c, d). Here, CASP3 is linked to Hepatic fibrosis.