Recent study has suggested that miR-196b-5p-mediated downregulation of Fas involved in the activation of STAT3 signaling through the NF-κBp65/IL-6 axis, and Fas downregulation could activate NF-κBp65 signaling to promote lung cancer cell growth in non-small cell lung cancer (NSCLC)48, which powerfully demonstrated the interaction between Fas/FasL and NF-κBp65. This evidence concerns the gene STAT3 and non-small cell lung carcinoma.