BBC3 and Hepatic fibrosis: By microanalysis screening for primary hepatocytes from mouse models, we found that PUMA (BBC3) in primary hepatocytes from fibrotic tissues presented a higher expression than that from normal tissues, while the Bcl-2 family members were not affected, it seems that the unchanged Bcl-2 family could not be enough to suppress the detrimental effects of PUMA during liver fibrosis (Supplementary Fig. 2b).