FAS and Hepatic fibrosis: To investigate the correlation between Fas/FasL and NF-κBp65 in liver fibrosis, liver specimens from humans and CCl4-induced mouse model were analyzed, and histological staining presented that, in contrast to the upregulation of Fas/FasL signaling in the fibrotic tissues, the activation of NF-κBp65 (phosphorylation of NF-κBp65, p-p65) was obviously repressed in the liver fibrotic tissues compared with their normal samples (Fig. 5a).