BBC3 and Hepatic fibrosis: We then examined the Bcl-2 family, which integrates a number of inter- and intracellular cues to determine whether or not the apoptosis pathway should be activated, and found that the pro-survival Bcl-2 family members were downregulated in hepatocytes with specific deletion of NF-κBp65, while the potent pro-apoptotic element PUMA was increased following NF-κBp65 deficiency in hepatocytes, which contributed to the development of liver fibrosis.