By adopting the TGF-β1 inhibitor pirfenidone, TNF-α inhibitor pentoxifylline, and monocytes depressor clodronate-loaded liposomes in p65Δhepa/PUMA-WT mice, we found inhibition of inflammatory action ameliorated liver fibrosis (Fig. 8b, c). Here, TNF is linked to Hepatic fibrosis.