DNGR-1 is a C-type lectin receptor highly restricted to cDC1s that senses necrosis.20–22 The infiltration of cDC1s within the TME has been revealed as a biomarker for improved overall survival in different types of cancer.1 2 4 This may be linked to their ability to cross-prime antitumor CD8+ T cells.7 8. The gene discussed is CD8A; the disease is cancer.