CLEC9A and viral infectious disease: DNGR-1 (CLEC9A) is a surface receptor with a highly restricted expression on cDC1s.17–19 DNGR-1 recognizes F-actin exposed on necrotic cells and mediates cross-presentation of dead cell-associated antigens,20–22 favoring the generation of tissue-resident memory CD8+ T cells after viral infections.11 Of note, DNGR-1 can also modulate signaling through heterologous receptors, restraining inflammation.23 However, whether DNGR-1 plays a role in antitumor immunity remains unexplored.