AKT1 and central nervous system cancer: Additionally, DANCR upregulates AXL, a receptor tyrosine kinase that activates the PI3K/Akt/NF-κB signaling pathway [32, 33] by competitively binding with miR-33a-5p, miRNA-33b-5p, miR-1-3p, miR-206 and miR-613 to mediate the cisplatin resistance in gliomas [34].