HULC silencing suppresses proliferation, adhesion, migration, invasion, and angiogenesis through the regulation of the cell cycle and anoikis, a Greek word for "homelessness" and a critical mechanism in preventing tumor cell apoptosis via a decrease in cell–matrix interaction, in the glioma by modulating endothelial cell-specific molecule 1 (ESM-1) expression via the PI3K/Akt/mTOR signaling pathway [36]. Here, AKT1 is linked to central nervous system cancer.