HIF1A and asthma: Furthermore, hematoxylin–eosin staining results demonstrated significant airway remodeling and increased thickening of the airway smooth muscles, airway wall, and airway epithelium mucosa in the asthma mice and mice with overexpressed YAP, overexpressed HIF-1α, or overexpressed miR-182, which was significantly inhibited by EGR2 overexpression (p < 0.05; Fig. 7g).