Therefore, we reasoned that miR-182 led to Th17 cell differentiation in pediatric asthma by targeting EGR2 as miR-182 is found capable of elevating the HIF-1α expression, thus promoting breast cancer cell proliferation and invasion [46], and such evidence implied positive correlation between miR-182 and HIF-1α. This evidence concerns the gene EGR2 and breast carcinoma.