ACTA1 and asthma: Besides, as α-SMA immunofluorescence staining results show, the expression of α-SMA was elevated in the lung tissues of asthma mice, which was also increased in the asthma mice treated with overexpressed YAP, overexpressed HIF-1α, or overexpressed miR-182, whereas EGR2 overexpression significantly inhibited the expression of α-SMA (Fig. 7f).