Largely in agreement with the results observed in human PBMCs, in mice with asthma, serum IL-17A content was significantly increased (Additional file 3: Fig. S3A, p < 0.05), RORγt was upregulated in spleen cells (Additional file 3: Fig. S3B, C, p < 0.05) accompanied by higher levels of YAP/HIF-1α (Additional file 3: Fig. S3D, E, p < 0.05), and lower HDL-C level (Additional file 3: Fig. S3F, p < 0.05) along with upregulation of miR-96/182/183 (p < 0.05), among which the increase in miR-182 expression was pronounced (Additional file 3: Fig. S3G, p < 0.05). The gene discussed is HIF1A; the disease is asthma.