In the current study, we aimed to investigate a potential molecular mechanism active in the development of asthma, and found that the YAP/HIF-1α factors could potentially augment Th17 cell differentiation, consequently exacerbating asthma and lipid metabolism dysfunction via miR-182-mediated EGR2 inhibition, thus providing a theoretical basis that could direct therapeutic strategies against asthma and lipid metabolic disorder. Here, HIF1A is linked to asthma.