STAT3 and inflammatory bowel disease: Moreover, methylated loci found in IBD, such as B cell lymphoma 3 protein (BCL3), signal transducer, and activator of transcription 3 (STAT3), oncostatin-M (OSM), and signal transducer and activator of transcription 5 (STAT5), are involved in regulation or downstream signaling in the Interleukin-23 (IL-23) signaling pathway [72].