When comparing inflamed and non-inflamed biopsies of adult CD patients, it is not surprising that specific IBD associated genes are altered in their methylation state, for example, unc-51 like autophagy activating kinase 1 (ULK1), docking protein 2 (DOK2), and antigen peptide transporter 1 (TAP1) [74]. Here, DOK2 is linked to Cowden disease.